HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6.

ABSTRACT: HOPS/Tmub1 is a ubiquitously expressed transmembrane ubiquitin-like protein that shuttles between nucleus and cytoplasm during cell cycle progression. HOPS causes cell cycle arrest in G₀/G₁ phase, an event associated to stabilization of p19^Arf, an important tumor suppressor protein. Moreover, HOPS plays an important role in driving centrosomal assembly and maintenance, mitotic spindle proper organization, and ultimately a correct cell division. Recently, HOPS has been described as an important regulator of p53, which acts as modifier, stabilizing p53 half-life and playing a key role in p53 mediating apoptosis after DNA damage. NF-κB is a transcription factor with a central role in many cellular events, including inflammation and apoptosis. Our experiments d

SUBMITTER: Bellet MM 

PROVIDER: S-EPMC7567074 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature