Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease.

ABSTRACT: The relationship between changes in body components and the risk of nonalcoholic fatty liver disease (NAFLD) is not fully understood. We investigated the effects of body components and subsequent changes on incident NAFLD at follow-up ultrasound scanning in a longitudinal cohort. We included 9967 participants without NAFLD at baseline who underwent serial health examinations. Sex-specific, weight-adjusted skeletal muscle index (SMI_{_Wt}) was used. Mean follow-up duration was 48.5 ± 33.5 months. NAFLD developed in 2395 participants (24.0%). Body composition was measured using bioelectrical impedance analysis. The following baseline body components were significantly associated with incident NAFLD: the lowest and middle SMI_{_Wt} tertiles in the normal-weight group (adjusted

SUBMITTER: Kim HY 

PROVIDER: S-EPMC7567080 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature