Association between muscle strength and advanced fibrosis in non-alcoholic fatty liver disease: a Korean nationwide survey.

ABSTRACT:

Background

We investigated the association between muscle strength and the prevalence of advanced fibrosis among individuals with non-alcoholic fatty liver disease (NAFLD) using a nationwide cross-sectional survey.

Methods

Individuals, 20 to 79 years of age, from the Korean National Health and Nutrition Examination Surveys (KNHANES) from 2014 to 2016 were selected (N = 14 861), with sample weights applied. Muscle strength was quantified as the handgrip strength divided by the body mass index (BMI); low muscle strength (LMS) was defined as the lowest quartile (Q₁ ) of the handgrip strength/BMI for our sample population. NAFLD was defined as hepatic steatosis index >36. Advanced fibrosis was defined as a fibrosis-4 index score ≥1.30 (Fibrosis_FIB4 ).

Re

SUBMITTER: Kang S 

PROVIDER: S-EPMC7567158 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature