Resistance to lean mass gain in constitutional thinness in free-living conditions is not overpassed by overfeeding.

ABSTRACT:

Background

Constitutional thinness (CT), a non-malnourished underweight state with no eating disorders, is characterized by weight gain resistance to high fat diet. Data issued from muscle biopsies suggested blunted anabolic mechanisms in free-living state. Weight and metabolic responses to protein caloric supplementation has not been yet explored in CT.

Methods

A 2 week overfeeding (additional 600 kcal, 30 g protein, 72 g carbohydrate, and 21 g fat) was performed to compare two groups of CTs (12 women and 11 men) to normal-weight controls (12 women and 10 men). Bodyweight, food intake, energy expenditure, body composition, nitrogen balance, appetite hormones profiles, and urine metabolome were monitored before and after overfeeding.

Results

Before overfeeding, positi

SUBMITTER: Ling Y 

PROVIDER: S-EPMC7567161 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature