Design and Characterization of a Novel Series of Geometrically Complex Intravaginal Rings with Digital Light Synthesis.

ABSTRACT: Intravaginal rings (IVRs) represent a sustained-release approach to drug delivery and have long been used and investigated for hormones and microbicides delivery. For decades, IVRs have been manufactured by injection molding and hot-melt extrusion with very limited design and material capabilities. Additive manufacturing (AM), specifically digital light synthesis (DLS), represents an opportunity to harness the freedom of design to expand control and tunability of drug release properties from IVRs. We report a novel approach to IVR design and manufacturing that results in geometrically complex internal architectures through the incorporation of distinct unit cells using computationally-aided design (CAD) software. We developed a systematic approach to design through the generation of an IVR

SUBMITTER: Janusziewicz R 

PROVIDER: S-EPMC7567335 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature