Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer's disease.

ABSTRACT:

Objective

In vivo functional changes in white matter during the progression of Alzheimer's disease (AD) have not been previously reported. Our objectives are to measure changes in white matter functional connectivity (FC) in an elderly population undergoing cognitive decline as AD develops, to establish their relationship to neuropsychological scores of cognitive abilities, and to assess the performance in prediction of AD using white matter FC measures as features.

Methods

Analyses were conducted using resting state functional MRI and neuropsychological data from 383 ADNI participants, including 136 cognitive normal (CN) controls, 46 with significant memory concern, 83 with early mild cognitive impairment (MCI), 37 with MCI, 46 with late MCI, and 35 with AD dementia. FC met

SUBMITTER: Gao Y 

PROVIDER: S-EPMC7567362 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature