The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress.

ABSTRACT: Pathogenic Leptospira spp. are the causative agents of the waterborne zoonotic disease leptospirosis. Leptospira are challenged by numerous adverse conditions, including deadly reactive oxygen species (ROS), when infecting their hosts. Withstanding ROS produced by the host innate immunity is an important strategy evolved by pathogenic Leptospira for persisting in and colonizing hosts. In L. interrogans, genes encoding defenses against ROS are repressed by the peroxide stress regulator, PerR. In this study, RNA sequencing was performed to characterize both the L. interrogans response to low and high concentrations of hydrogen peroxide and the PerR regulon. We showed that Leptospira solicit three main peroxidase machineries (catalase, cytochrome C peroxidase and peroxiredoxin) and heme to de

SUBMITTER: Zavala-Alvarado C 

PROVIDER: S-EPMC7567364 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature