Optimising age coverage of seasonal influenza vaccination in England: A mathematical and health economic evaluation.

ABSTRACT: For infectious disease prevention, policy-makers are typically required to base policy decisions in light of operational and monetary restrictions, prohibiting implementation of all candidate interventions. To inform the evidence-base underpinning policy decision making, mathematical and health economic modelling can be a valuable constituent. Applied to England, this study aims to identify the optimal target age groups when extending a seasonal influenza vaccination programme of at-risk individuals to those individuals at low risk of developing complications following infection. To perform this analysis, we utilise an age- and strain-structured transmission model that includes immunity propagation mechanisms which link prior season epidemiological outcomes to immunity at the beginning of

SUBMITTER: Hill EM 

PROVIDER: S-EPMC7567368 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature