Epigenomics-based identification of oestrogen-regulated long noncoding RNAs in ER+ breast cancer.

ABSTRACT: Breast cancer is one of the most prevalent cancers in women worldwide. Through the regulation of many coding and non-coding target genes, oestrogen (E₂ or 17β-oestradiol) and its nuclear receptor ERα play important roles in breast cancer development and progression. Despite the astounding advances in our understanding of oestrogen-regulated coding genes over the past decades, our knowledge on oestrogen-regulated non-coding targets has just begun to expand. Here we leverage epigenomic approaches to systematically analyse oestrogen-regulated long non-coding RNAs (lncRNAs). Similar to the coding targets of ERα, the transcription of oestrogen-regulated lncRNAs correlates with the activation status of ERα enhancers, measured by eRNA production, chromatin accessibility, and the occupa

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7567493 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature