Modulation of voltage-gated Ca_V2.2 Ca²⁺ channels by newly identified interaction partners.

ABSTRACT: Voltage-gated Ca²⁺ channels are typically integrated in a complex network of protein-protein-interactions, also referred to as Ca²⁺ channel nanodomains. Amongst the neuronal Ca_V2 channel family, Ca_V2.2 is of particular importance due to its general role for signal transmission from the periphery to the central nervous system, but also due to its significance for pain perception. Thus, Ca_V2.2 is an ideal target candidate to search for pharmacological inhibitors but also for novel modulatory interactors. In this review we summarize the last years findings of our intense screenings and characterization of the six Ca_V2.2 interaction partners, tetraspanin-13 (TSPAN-13), reticulon 1 (RTN1), member 1 of solute carrier family 38 (SL

SUBMITTER: Lacinova L 

PROVIDER: S-EPMC7567506 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature