Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance.

ABSTRACT: Mouse and rats are staple model organisms that have been traditionally used for oncological studies; however, their short lifespan and highly prone to cancers limit their utilizationsin understanding the mechanisms of cancer resistance. In recent years, several studies of the non-standard long-lived mammalian species like naked mole rat (NMR) have provided new insights of mechanisms in natural anti-cancer. How long-lived species genetically maintain longevity and cancer-resistance remains largely elusive. To better understand the underlying anti-cancer mechanisms in long-lived mammals, we genome widely identified long noncoding RNA (lncRNA) transcripts of two longevous mammals, bowhead whale (BW, Balaena mysticetus) and Brandt's bat (BB, Myotis brandtii) and featured their se

SUBMITTER: Jiang JJ 

PROVIDER: S-EPMC7567513 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature