Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease.

ABSTRACT: Antigen-specific particles can treat autoimmunity, and pulmonary delivery may provide for easier delivery than intravenous or subcutaneous routes. The lung is a "hub" for autoimmunity where autoreactive T cells pass before arriving at disease sites. Here, we report that targeting lung antigen-presenting cells (APCs) via antigen-loaded poly(lactide-co-glycolide) particles modulates lung CD4+ T cells to tolerize murine experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Particles directly delivered to the lung via intratracheal administration demonstrated more substantial reduction in EAE severity when compared with particles delivered to the liver and spleen via intravenous administration. Intratracheally delivered particles were associated with lung APCs a

SUBMITTER: Saito E 

PROVIDER: S-EPMC7567592 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature