γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis.

ABSTRACT: This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them to compose a unique local T-cell compartment. Consistent with earlier reports, most cells expressed a canonical Vγ6Vδ1 TCR, and produced interleukin (IL)-17A upon stimulation. Nonetheless, contrasting with earlier reports, uterine γδ T cells were not obviously intraepithelial, being more akin to sub-epithelial Vγ6Vδ1⁺ T cells at several other anatomical sites. By contrast to other tissues however, the uterine compartment also included non-Vγ6⁺, IFN-γ-producing cells; was strikingly enriched in young mice; expressed genes hitherto associated with the uterus, including the progesterone receptor; and did not require microbes for development and/or maintenance. This notwithstanding, γ

SUBMITTER: Monin L 

PROVIDER: S-EPMC7567646 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature