Regional [¹⁸F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer's disease.

ABSTRACT:

Purpose

In vivo Alzheimer's disease (AD) biomarkers for tau pathology are cerebrospinal fluid (CSF) phosphorylated tau (p-tau) and [¹⁸F]flortaucipir positron emission tomography (PET). Our aim was to assess associations between CSF p-tau with [¹⁸F]flortaucipir PET and the associations of both tau biomarkers with cognition and atrophy.

Methods

We included 78 amyloid positive cognitively impaired patients (clinical diagnoses mild cognitive impairment (MCI, n = 8) and AD dementia (n = 45) and 25 cognitively normal subjects with subjective cognitive decline (SCD) (40% amyloid-positive)). Dynamic 130 min [¹⁸F]flortaucipir PET scans were acquired to generate binding potential (BP_ND) images using receptor parametric mapping and standardiz

SUBMITTER: Wolters EE 

PROVIDER: S-EPMC7567681 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature