Early-phase [¹⁸F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury.

ABSTRACT:

Purpose

Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [¹⁸F]PI-2620 as a potential substitute for [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG).

Methods

Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's diseas

SUBMITTER: Beyer L 

PROVIDER: S-EPMC7567714 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature