SNORA71B promotes breast cancer cells across blood-brain barrier by inducing epithelial-mesenchymal transition.

ABSTRACT:

Background

Brain metastasis (BM) is a dreadful complication that significantly impacts the quality of life in breast cancer patients. A key process during brain metastasis is the migration of cancer cells across blood-brain barrier (BBB). However, the role of snoRNAs regulating BBB in BM is still unknown.

Methods

Here SNORic and GEO databases were used to identify differentially expressed snoRNAs between brain metastatic and non-metastatic breast cancer (BC) tissues. The effects of SNORA71B on the capacities of proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and BBB invasion of BC cells were evaluated by CCK8, transwell, western blot, and BBB model, respectively.

Results

SNORA71B was highly expressed in high BM BC tissues and cells compare

SUBMITTER: Duan S 

PROVIDER: S-EPMC7567732 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature