Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice.

ABSTRACT: Mounting evidence suggests that gut microbiota can play an important role in pathophysiology of depression, but its specific molecular mechanisms are still unclear. This study was conducted to explore the associations between changes in neurotransmitters and short-chain fatty acids (SCFAs) and altered gut microbiota in depressed mice. Here, the chronic restraint stress (CRS) model of depression was built. The classical behavioral tests were conducted to assess the depressive-like behaviors of mice. The 16S rRNA gene sequence extracted from fecal samples was used to assess the gut microbial composition. Liquid and gas chromatography mass spectroscopy were used to identify neurotransmitters in hypothalamus and SCFAs in fecal samples, respectively. Finally, 29 differential bacteria taxa betwe

SUBMITTER: Wu M 

PROVIDER: S-EPMC7567879 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature