Global gene expression profiling of blast lung injury of goats exposed to shock wave.

ABSTRACT:

Purpose

Blast lung injury (BLI) is the most common damage resulted from explosion-derived shock wave in military, terrorism and industrial accidents. However, the molecular mechanisms underlying BLI induced by shock wave are still unclear.

Methods

In this study, a goat BLI model was established by a fuel air explosive power. The key genes involved in were identified. The goats of the experimental group were fixed on the edge of the explosion cloud, while the goats of the control group were 3 km far away from the explosive environment. After successful modeling for 24 h, all the goats were sacrificed and the lung tissue was harvested for histopathological observation and RNA sequencing. Gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) analysis were perfor

SUBMITTER: Wang H 

PROVIDER: S-EPMC7567904 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature