Δ42PD1-TLR4 Augments γδ-T Cell Activation of the Transitional Memory Subset of CD4⁺ T Cells.

ABSTRACT: TLR ligands can contribute to T cell immune responses by indirectly stimulating antigen presentation and cytokines and directly serving as co-stimulatory signals. We have previously reported that the human endogenous surface protein, Δ42PD1, is expressed primarily on (Vγ9)Vδ2 cells and can interact with TLR4. Since Vδ2 cells possess antigen presentation capacity, we sought to further characterize if the Δ42PD1-TLR4 interaction has a role in stimulating T cell responses. In this study, we found that stimulation of Vδ2 cells not only upregulated Δ42PD1 expression but also increased MHC class II molecules necessary for the antigen presentation. In a mixed leukocyte reaction assay, upregulation of Δ42PD1 on Vδ2 cells elevated subsequent T cell proliferation. Furthermore, the interaction betwee

SUBMITTER: Mo Y 

PROVIDER: S-EPMC7567942 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature