Aberrant Advanced Cognitive and Attention-Related Brain Networks in Parkinson's Disease with Freezing of Gait.

ABSTRACT:

Background

Freezing of gait (FOG) is a disabling gait disorder influencing patients with Parkinson's disease (PD). Accumulating evidence suggests that FOG is related to the functional alterations within brain networks. We investigated the changes in brain resting-state functional connectivity (FC) in patients with PD with FOG (FOG+) and without FOG (FOG-).

Methods

Resting-state functional magnetic resonance imaging (RS-fMRI) data were collected from 55 PD patients (25 FOG+ and 30 FOG-) and 26 matched healthy controls (HC). Differences in intranetwork connectivity between FOG+, FOG-, and HC individuals were explored using independent component analysis (ICA).

Results

Seven resting-state networks (RSNs) with abnormalities, including motor, executive, and cognitive-relat

SUBMITTER: Li Y 

PROVIDER: S-EPMC7568140 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature