Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence.

ABSTRACT: Cellular senescence plays a very important role in organismal aging increasing with age and in age-related diseases (ARDs). This process involves physiological, structural, biochemical, and molecular changes of cells, leading to a characteristic trait referred to "senescence-associated secretory phenotype (SASP)." In particular, with aging, stem cells (SCs) in situ exhibit a diminished capacity of self-renewal and show a decline in their functionality. The identification of interventions able to prevent the accumulation of senescent SCs in the organism or to pretreat cultured multipotent mesenchymal stromal cells (MSCs) prior to employing them for cell therapy is a main purpose of medical research. Many approaches have been investigated and resulted effective to prevent or counterac

SUBMITTER: Abruzzo PM 

PROVIDER: S-EPMC7568162 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature