Association Use of Bisphosphonates with Risk of Breast Cancer: A Meta-Analysis.

ABSTRACT:

Background

Previous studies have investigated the association between the use of bisphosphonates and the development of breast cancer, which presented controversial results. Thus, this meta-analysis was conducted to summarize the current evidence of the association of bisphosphonate use with breast cancer risk.

Methods

A comprehensive search was conducted in PubMed, ISI Web of Knowledge, the Cochrane Library, and Embase from inception to March 2019 by two researches, who independently selected trials, retrieved relevant data, and assessed study quality. The summary relative risk (RR) for the use of bisphosphonates on the risks of developing breast cancer was calculated using a random-effect model.

Results

The present meta-analysis, which included four case-control stu

SUBMITTER: Peng R 

PROVIDER: S-EPMC7568169 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature