Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.

ABSTRACT: Memory CD8 T cells provide durable protection against diverse intracellular pathogens and can be broadly segregated into distinct circulating and tissue-resident populations. Paradigmatic studies have demonstrated that circulating memory cells can be further divided into effector memory (Tem) and central memory (Tcm) populations based on discrete functional characteristics. Following resolution of infection, we identified a persisting antigen-specific CD8 T cell population that was terminally fated with potent effector function but maintained memory T cell qualities and conferred robust protection against reinfection. Notably, this terminally differentiated effector memory CD8 T cell population (terminal-Tem) was conflated within the conventional Tem population, prompting redefinition of t

SUBMITTER: Milner JJ 

PROVIDER: S-EPMC7568335 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature