Network analysis of autistic disease comorbidities in Chinese children based on ICD-10 codes.

ABSTRACT:

Background

Autism is a lifelong disability associated with several comorbidities that confound diagnosis and treatment. A better understanding of these comorbidities would facilitate diagnosis and improve treatments. Our aim was to improve the detection of comorbid diseases associated with autism.

Methods

We used an FP-growth algorithm to retrospectively infer disease associations using 1488 patients with autism treated at the Guangzhou Women and Children's Medical Center. The disease network was established using Cytoscape 3.7. The rules were internally validated by 10-fold cross-validation. All rules were further verified using the Columbia Open Health Data (COHD) and by literature search.

Results

We found 148 comorbid diseases including intellectual disability, dev

SUBMITTER: Li X 

PROVIDER: S-EPMC7568351 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature