Signaling pathways have an inherent need for noise to acquire information.

ABSTRACT:

Background

All living systems acquire information about their environment. At the cellular level, they do so through signaling pathways. Such pathways rely on reversible binding interactions between molecules that detect and transmit the presence of an extracellular cue or signal to the cell's interior. These interactions are inherently stochastic and thus noisy. On the one hand, noise can cause a signaling pathway to produce the same response for different stimuli, which reduces the amount of information a pathway acquires. On the other hand, in processes such as stochastic resonance, noise can improve the detection of weak stimuli and thus the acquisition of information. It is not clear whether the kinetic parameters that determine a pathway's operation cause noise to reduce or i

SUBMITTER: Azpeitia E 

PROVIDER: S-EPMC7568421 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature