Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury.

ABSTRACT:

Background

Sepsis-related acute kidney injury (AKI) is associated with high morbidity and mortality among patients. Underlying pathomechanisms include capillary leakage and fluid loss into the interstitial tissue and constant exposure to pathogens results in activation of inflammatory cascades, organ dysfunction and subsequently organ damage.

Methods

To identify novel factors that trigger sepsis-related acute kidney injury, plasma levels of Granzyme A, as representative of a lymphocyte-derived protease, and heparin-binding protein as indicator for neutrophil-derived mediators, were investigated retrospectively in 60 sepsis patients.

Results

While no association was found between plasma levels of lymphocyte-derived Granzyme A and the incidence of sepsis-related AKI, se

SUBMITTER: Pajenda S 

PROVIDER: S-EPMC7568480 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature