Endogenous hydrogen sulfide maintains eupnea in an in situ arterially perfused preparation of rats.

ABSTRACT: Hydrogen sulfide (H₂S) is constitutively generated in the human body and works as a gasotransmitter in synaptic transmission. In this study, we aimed to evaluate the roles of endogenous H₂S in generating eupnea at the respiratory center. We employed an in situ arterially perfused preparation of decerebrated rats and recorded the central respiratory outputs. When the H₂S-producing enzyme cystathionine β-synthase (CBS) was inhibited, respiration switched from the 3-phase eupneic pattern, which consists of inspiration, postinspiration, and expiration, to gasping-like respiration, which consists of inspiration only. On the other hand, when H₂S synthesis was inhibited via cystathionine γ-lyase (CSE) or when H₂S synthesis was activated via C

SUBMITTER: Okazaki M 

PROVIDER: S-EPMC7568547 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature