Dataset Information

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4⁺ T cells to reduce the latent HIV⁺ cell reservoir.

ABSTRACT: Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4⁺ target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.

SUBMITTER: Patasic L

PROVIDER: S-EPMC7568711 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Dataset Information

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4⁺ T cells to reduce the latent HIV⁺ cell reservoir.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4⁺ T cells to reduce the latent HIV⁺ cell reservoir.