CBX3 Promotes Gastric Cancer Progression and Affects Factors Related to Immunotherapeutic Responses.

ABSTRACT:

Background

Chromobox 3 (CBX3) is a member of the chromobox family proteins, which plays a critical role in tumor progression, but the exact function of CBX3 in gastric cancer remains unknown. The current research mainly investigates the underlying mechanisms and clinical value of CBX3 in gastric cancer.

Methods

Gene expression cohorts from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed to assess the effect of CBX3 in gastric cancer. CBX3 expression was further determined by immunohistochemistry (IHC). The function of CBX3 on proliferation, migration and the cell cycle was explored via colony-forming, cell cycle and transwell assays, respectively. Moreover, RNA sequencing (RNA-seq) in AGS cells and two cohorts was utilized to explore the specif

SUBMITTER: Lin H 

PROVIDER: S-EPMC7569062 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature