Gastroprotective activity of Hypericum perforatum extract in ethanol-induced gastric mucosal injury in Wistar rats: A possible involvement of H+/K+ ATPase α inhibition.

ABSTRACT: Hypericum perforatum (HP) is a plant native to Asia and Europe. It has been documented to enclose medical effects against many disorders such as anxiety, depression and burns. This experiment was performed to evaluate the gastro-protective effect of Hypericum perforatum leaf extract in ethanol induced gastric ulcer in rats as compared to esomeprazole (the drug of choice for stomach ulcers). The mechanism of action was performed by Auto Dock Vina method. Ethanol ingestion up regulated the inflammatory reaction as demonstrated by rise of gastric proinflammatory TNF-α with a decline of IL-1β. On the other hand, the phytochemical screening of HP revealed the presence of alkaloids, flavonoids, tannins, phenols, steroids and saponins. The high dose of HP group shows mild injuries t

SUBMITTER: Sofi SH 

PROVIDER: S-EPMC7569342 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature