Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis.

ABSTRACT:

Objective

Genome-wide association studies (GWAS) in rheumatoid arthritis (RA) have discovered over 100 RA loci, explaining patient-relevant RA pathogenesis but showing a large fraction of missing heritability. As a continuous effort, we conducted GWAS in a large Korean RA case-control population.

Methods

We newly generated genome-wide variant data in two independent Korean cohorts comprising 4068 RA cases and 36 487 controls, followed by a whole-genome imputation and a meta-analysis of the disease association results in the two cohorts. By integrating publicly available omics data with the GWAS results, a series of bioinformatic analyses were conducted to prioritise the RA-risk genes in RA loci and to dissect biological mechanisms underlying disease associations.

Results<

SUBMITTER: Kwon YC 

PROVIDER: S-EPMC7569386 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature