Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients.

ABSTRACT:

Objective

The gut microbiota has been proposed as an interesting therapeutic target for metabolic disorders. Inulin as a prebiotic has been shown to lessen obesity and related diseases. The aim of the current study was to investigate whether preintervention gut microbiota characteristics determine the physiological response to inulin.

Design

The stools from four obese donors differing by microbial diversity and composition were sampled before the dietary intervention and inoculated to antibiotic-pretreated mice (hum-ob mice; humanised obese mice). Hum-ob mice were fed with a high-fat diet and treated with inulin. Metabolic and microbiota changes on inulin treatment in hum-ob mice were compared with those obtained in a cohort of obese individuals suppleme

SUBMITTER: Rodriguez J 

PROVIDER: S-EPMC7569399 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature