Multiplexed cytokine detection using electrochemical point-of-care sensing device towards rapid sepsis endotyping.

ABSTRACT: The implementation of endotype-driven effective intervention strategies is now considered as an essential component for sepsis management. Rapid screening and frequent monitoring of immune responses are critical for evidence-based informed decisions in the early hours of patient arrival. Current technologies focus on pathogen identification that lack rapid testing of the patient immune response, impeding clinicians from providing appropriate sepsis treatment. Herein, we demonstrate a first-of-its-kind novel point-of-care device that uses a unique approach by directly monitoring a panel of five cytokine biomarkers (IL-6, IL-8, IL-10, TRAIL & IP-10), that is attributed as a sign of the body's host immune response to sepsis. The developed point-of-care device encompasses a disposable sensor c

SUBMITTER: Tanak AS 

PROVIDER: S-EPMC7569407 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature