CEN-tools: an integrative platform to identify the contexts of essential genes.

ABSTRACT: An emerging theme from large-scale genetic screens that identify genes essential for cell fitness is that essentiality of a given gene is highly context-specific. Identification of such contexts could be the key to defining gene function and also to develop novel therapeutic interventions. Here, we present Context-specific Essentiality Network-tools (CEN-tools), a website and python package, in which users can interrogate the essentiality of a gene from large-scale genome-scale CRISPR screens in a number of biological contexts including tissue of origin, mutation profiles, expression levels and drug responses. We show that CEN-tools is suitable for the systematic identification of genetic dependencies and for more targeted queries. The associations between genes and a given context are rep

SUBMITTER: Sharma S 

PROVIDER: S-EPMC7569414 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature