Association of BsmI variant of vitamin D receptor gene with polycystic ovary syndrome: A case-control study.

ABSTRACT:

Background

Polycystic ovarian syndrome (PCOS) is an endocrine disorder that affects women's fertility and causes alterations such as obesity, insulin resistance, menstrual irregularities, and polycystic ovaries. The results of the studies show that the issue of vitamin D and vitamin D receptor (VDR) is controversial for PCOS susceptibility.

Objective

To investigate the association of BsmI polymorphism in the VDR gene with metabolic parameters in obese PCOS women.

Materials and methods

In this case-control study, 38 obese subjects with PCOS and 40 unrelated obese individuals were evaluated to determine the allelic and genotypic frequency of BsmI variant by Polymerase Chain Reaction Restriction Fragment Length Polymorphism method. Body Mass Index, p

SUBMITTER: Ramezani N 

PROVIDER: S-EPMC7569712 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature