Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa.

ABSTRACT: Pseudomonas aeruginosa is a significant human pathogen, it possesses almost all of the known antimicrobial resistance mechanisms. Quorum sensing (QS) is an intercellular communication system that orchestrates bacterial virulence and its targeting is an effective approach to diminish its pathogenesis. Repurposing of drugs is an advantageous strategy, in this study we aimed to repurpose the anti-diabetic drugs sitagliptin, metformin and vildagliptin as anti-QS in P. aeruginosa. The effects of sub-inhibitory concentrations of the tested drugs on the expression of QS-encoding genes and QS-regulated virulence factors were assessed. The protective activity of tested drugs on P. aeruginosa pathogenesis was evaluated in vivo on mice. In silico analysis was performed to evaluat

SUBMITTER: Hegazy WAH 

PROVIDER: S-EPMC7569791 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature