Platelet transfusion for neonates with thrombocytopaenia: protocol for a systematic review.

ABSTRACT:

Introduction

Thrombocytopaenia is one of the most common haemostatic abnormalities among neonates. It affects approximately one-quarter of neonates admitted into neonatal intensive care units and may lead to a high risk of bleeding and mortality, which are substantial causes for concern by neonatologists. Platelet transfusion (PT) is a specific treatment for thrombocytopaenia. To date, PT thresholds are diverse since the associations between low platelet count and negative outcomes are not clear. We propose this protocol for a systematic review to collect and assess evidence concerning the best PT threshold to reduce mortality, bleeding and major morbidity among neonates with thrombocytopaenia.

Methods and analysis

The systematic review will be performed according to the Coc

SUBMITTER: Liu D 

PROVIDER: S-EPMC7569922 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature