White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile.

ABSTRACT:

Background

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have high rates of co-occurrence and share atypical behavioral characteristics, including sensory symptoms. The present diffusion tensor imaging (DTI) study was conducted to examine whether and how white matter alterations are observed in adult populations with developmental disorders (DD) and to determine how brain-sensory relationships are either shared between or distinct to ASD and ADHD.

Methods

We collected DTI data from adult population with DD (a primary diagnosis of ASD: n = 105, ADHD: n = 55) as well as age- and sex-matched typically developing (TD) participants (n = 58). Voxel-wise fractional anisotropy (FA), mean diffusivity, axial diffusivity, and radial diffusivity (RD)

SUBMITTER: Ohta H 

PROVIDER: S-EPMC7570037 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature