Biological Aging Modulates Cell Migration via Lamin A/C-Dependent Nuclear Motion.

ABSTRACT: Aging is a progressive functional decline in organs and tissues over time and typically represents the accumulation of psychological and social changes in a human being. Diverse diseases, such as cardiovascular, musculoskeletal, and neurodegenerative disorders, are now understood to be caused by aging. While biological assessment of aging mainly focuses on the gradual changes that occur either on the molecular scale, for example, alteration of gene expression and epigenetic modification, or on larger scales, for example, changes in muscle strength and cardiac function, the mechanics that regulates the behavior of individual cells and interactions between the internal elements of cells, are largely missing. In this study, we show that the dynamic features of migrating cells across different

SUBMITTER: Park JW 

PROVIDER: S-EPMC7570206 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature