Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.

ABSTRACT:

Background

Acute lung injury (ALI) is a serious disease with highly morbidity and mortality that causes serious health problems worldwide. Atypical mitogen activated protein kinases (MAPKs) play critical roles in the development of tissues and have been proposed as promising therapeutic targets for various diseases. However, the potential role of atypical MAPKs in ALI remains elusive. In this study, we investigated the role of atypical MAPKs family member MAPK4 in ALI using LPS-induced murine ALI model.

Results

We found that MAPK4 deficiency mice exhibited prolonged survival time after LPS challenge, accompanied by alleviated pathology in lung tissues, decreased levels of pro-inflammatory cytokines and altered composition of immune cells in BALF. Furthermore, the transductio

SUBMITTER: Mao L 

PROVIDER: S-EPMC7570399 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature