Alternating magnetic field mediated release of fluorophores from magnetic nanoparticles by hysteretic heating.

ABSTRACT: This study explores the use of differential heating of magnetic nanoparticles with different sizes and compositions (MFe₂O₄ (M = Fe, Co)) for heteroplexed temporal controlled release of conjugated fluorophores from the surface of nanoparticles. By exploiting these differences, we were able to control the amount of hysteretic heating occurring with the distinct sets of magnetic nanoparticles using the same applied alternating magnetic field radio frequency (AMF-RF). Using thermally labile retro-Diels-Alder linkers conjugated to the surface of nanoparticles, the fluorescent payload from the different nanoparticles disengaged when sufficient energy was locally generated during hysteretic heating. 1H, 13C NMR, ESI-MS, and SIMS characterized the thermally responsive fluore

SUBMITTER: Casey JS 

PROVIDER: S-EPMC7570445 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature