Synthesis and Biological Evaluation of Novel Benodanil-Heterocyclic Carboxamide Hybrids as a Potential Succinate Dehydrogenase Inhibitors.

ABSTRACT: In order to discover new antifungal agents, twenty novel benodanil-heterocyclic carboxamide hybrids were designed, synthesized, and characterized by ¹H NMR and HRMS. In vitro, their antifungal activities against four phytopathogenic fungi were evaluated, as well as some of the target compounds at 50 mg/L demonstrated significant antifungal activities against Rhizoctonia solani. Especially, compounds 17 (EC₅₀ = 6.32 mg/L) and 18 (EC₅₀ = 6.06 mg/L) exhibited good antifungal activities against R. solani and were superior to the lead fungicide benodanil (a succinate dehydrogenase inhibitor, SDHI) (EC₅₀ = 6.38 mg/L). Furthermore, scanning electron microscopy images showed that the mycelia on treated media with the addition

SUBMITTER: Yang J 

PROVIDER: S-EPMC7570671 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature