UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer.

ABSTRACT: Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF4: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.

SUBMITTER: Guryev EL 

PROVIDER: S-EPMC7571190 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature