A Ketogenic & Low-Protein Diet Slows Retinal Degeneration in rd10 Mice.

ABSTRACT:

Purpose

Treatments that delay retinal cell death regardless of genetic causation are needed for inherited retinal degeneration (IRD) patients. The ketogenic diet is a high-fat, low-carbohydrate diet, used to treat epilepsy, and has beneficial effects for neurodegenerative diseases. This study aimed to determine whether the ketogenic diet could slow retinal degeneration.

Methods

Early weaned, rd10 and wild-type (WT) mice were placed on either standard chow, a ketogenic diet, or a ketogenic & low-protein diet. From postnatal day (PD) 23 to PD50, weight and blood β-hydroxybutyrate levels were recorded. Retinal thickness, retinal function, and visual performance were measured via optical coherence tomography, electroretinography (ERG), and optokinetic tracking (OKT). At PD40, se

SUBMITTER: Ryals RC 

PROVIDER: S-EPMC7571290 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature