Hormone References for Ultrasound Breast Staging and Endocrine Profiling to Detect Female Onset of Puberty.

ABSTRACT: Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement this method. Furthermore, previous studies have not explored the predictive value of endocrine profiling to determine female puberty onset. To integrate US breast staging with hypothalamic-pituitary-gonadal hormone references and test the predictive value of an endocrine profile to determine thelarche. Cross-sectional sample of 601 healthy Norwegian girls, ages 6 to 16 years. Clinical and ultrasound breast evaluations were performed for all included girls. Blood samples were analyzed by immunoassay and ultrasensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) to

SUBMITTER: Madsen A 

PROVIDER: S-EPMC7571452 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature