Identification of Four Immune Subtypes in Bladder Cancer Based on Immune Gene Sets.

ABSTRACT: Molecular classification of bladder cancer is becoming increasingly important for its clinical management. And, the current classifications are primarily based on gene expression profiles. We identified four immunotypes of bladder cancer (referred to as C1-C4) based on gene expression profiles performed by immune-related gene sets in three independent data sets, and proved that this classification is effective and reproducible. We found that C2 is an immune-infiltrating type and C4 is an immune "desert" type. These types are characterized by the up- and downregulation of genes encoding numerous immune checkpoint proteins and HLA and regulating human immune cell subgroups. The survival rate was better for the C2 subtype than for other subtypes. We believe that this can be explained by the a

SUBMITTER: Tang C 

PROVIDER: S-EPMC7571508 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature