Effectiveness of Progestogens as Maintenance Tocolysis and Urogenital Cultures: Secondary Analysis of the PROTECT Trial.

ABSTRACT: Background  In a recently published multicenter randomized controlled trial, we demonstrated that progestogens are not effective as maintenance tocolysis. Objective  This study was aimed to evaluate if previous finding may be affected by positive urine culture and/or vaginal swab. Study Design  We performed a secondary analysis of the PROTECT trial (NCT01178788). Women with singleton pregnancy between 22 and 31 ^6/7 weeks' gestation, admitted for threatened preterm labor were considered. At admission, we collected urine culture and vaginal swabs. At discharge, women with a cervical length ≤25 mm were randomized to vaginal progesterone or 17α-hydroxyprogesterone caproate or observation group. We used Chi-square statistics, considering 97.5% CI (confidence inte

SUBMITTER: Pignatti L 

PROVIDER: S-EPMC7571568 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature