Mutation bias interacts with composition bias to influence adaptive evolution.

ABSTRACT: Mutation is a biased stochastic process, with some types of mutations occurring more frequently than others. Previous work has used synthetic genotype-phenotype landscapes to study how such mutation bias affects adaptive evolution. Here, we consider 746 empirical genotype-phenotype landscapes, each of which describes the binding affinity of target DNA sequences to a transcription factor, to study the influence of mutation bias on adaptive evolution of increased binding affinity. By using empirical genotype-phenotype landscapes, we need to make only few assumptions about landscape topography and about the DNA sequences that each landscape contains. The latter is particularly important because the set of sequences that a landscape contains determines the types of mutations that can occur alo

SUBMITTER: Cano AV 

PROVIDER: S-EPMC7571706 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature