Biophysically detailed mathematical models of multiscale cardiac active mechanics.

ABSTRACT: We propose four novel mathematical models, describing the microscopic mechanisms of force generation in the cardiac muscle tissue, which are suitable for multiscale numerical simulations of cardiac electromechanics. Such models are based on a biophysically accurate representation of the regulatory and contractile proteins in the sarcomeres. Our models, unlike most of the sarcomere dynamics models that are available in the literature and that feature a comparable richness of detail, do not require the time-consuming Monte Carlo method for their numerical approximation. Conversely, the models that we propose only require the solution of a system of PDEs and/or ODEs (the most reduced of the four only involving 20 ODEs), thus entailing a significant computational efficiency. By focusing on the

SUBMITTER: Regazzoni F 

PROVIDER: S-EPMC7571720 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature