Biomarkers in previous histologically negative prostate biopsies can be helpful in repeat biopsy decision-making processes.

ABSTRACT: To evaluate whether the addition of biomarkers to traditional clinicopathological parameters may help to increase the accurate prediction of prostate re-biopsy outcome. A training cohort with 98 patients and a validation cohort with 72 patients were retrospectively recruited into our study. Immunohistochemical analysis was used to evaluate the immunoreactivity of a group of biomarkers in the initial negative biopsy normal-looking tissues of the training and validation cohorts. p-STAT3, Mcm2, and/or MSR1 were selected out of 10 biomarkers to construct a biomarker index for predicting cancer and high-grade prostate cancer (HGPCa) in the training cohort based on the stepwise logistic regression analysis; these biomarkers were then validated in the validation cohort. In the training cohort stu

SUBMITTER: Long X 

PROVIDER: S-EPMC7571822 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature